Fourier Transform Infrared Spectroscopy(FTIR), is a powerful analytical technique used in chemistry, materials science, and various other fields.
It enables the identification and analysis of different compounds based on their unique infrared absorption patterns. The principle behind FTIR involves the interaction of infrared radiation with a sample material.
When infrared light is passed through a sample, certain frequencies of the light are absorbed by the sample's molecules, causing them to vibrate. The specific frequencies absorbed are characteristic of the molecular structure of the material.

NAIRDB hosts a series of experiments originating from the synchrotron SOLEIL, as well as data adopted from the literature. The experimental data include the spectra of DNA, RNA, DNA/RNA hybrids, and other nucleic acid molecules. Importantly, all datasets are carefully analyzed and validated by FTIR experts. We also present 3D structural models for the nucleic acid molecules analyzed to illustrate the structural complexity of the molecules analyzed.

For improvements or suggestions, please use our contact form. Please use the contact form also to notify us if you want to provide us with new data. We will get back to you as soon as possible discussing about the data and the format. Proposed spectra must have been pubished !

The NAIRDB website is free, open to all users and there is no login required. The data is freely accessible for research and academic purposes. Industry users interested in commercial use of NAIRDB data are encouraged to contact us.

NAIRDB hosts nucleotide sequences with modified residues. Each modified nucleotide is represented with the standard notation used in the MODOMICS database. Furthermore, each of the modified residue contains a link to the relative page of the MODOMICS database.

NAIRDB presents data for many different types of nucleic acid structures. The basic classification includes the following classes:

1. ss : single stranded (non-base paired single-stranded nucleic acid

2. ds : doubled stranded (duplex involving canonical (A•T, G•C, A•U) or Hoogsteen base pairs; specific duplexes can be antiparallel or parallel)

3. ts : triple stranded (structure involving canonical duplex and a 3rd Pu or Py strand paired using Hoogsteen hydrogen bonds)

4. qs : quadruple stranded (structure involving base pairing among 4 strands of nucleic acid; in a G-quadruplex, guanines form a ring stabilized by Hoogsteen hydrogen bonds and 3 or more rings stack into a 4-stranded structure comprised of parallel or antiparallel strands)

5. g : genomic (mixed sequence sample comprised of an entire genome

6. i-motif : i-motif (tetrameric structure from two intercalated (C•C+)n duplexes

Moiety Subtypes, useful for searching the database, include :